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Advinus



Pharmaceutical Development
Services for REACH
We are prepared to meet all the physico-chemical, toxicity and environmental fate testing needs in cost-effective manner. Below are the details of our offering.
Physical-Chemical Properties
  • Physical state at 20°C and 101.3 kPa
  • Melting/freezing point
  • Boiling point
  • Relative density
  • Vapor pressure
  • Surface tension
  • Water solubility
  • Partition coefficient n-octanol/water (log value)
  • Flash point
  • Flammability
  • Stability in organic solvents and identity of relevant degradation products
  • Dissociation constant
  • Viscosity
Toxicology
  • Sensitization (LLNA)
  • Acute toxicity oral
  • Mutagenicity (Ames Test)
  • In vivo skin irritation
  • In vivo eye irritation
  • Acute toxicity (Dermal, Inhalation, Oral)
  • Mutagenicity (in vitro gene mutation – mammalian cells)
  • Mutagenicity (in vitro cytogenicity in mammalian cells)
  • Reproductive toxicity
  • Developmental screen (OECD 421 or 422)
  • Repeated dose toxicity (28 days)
  • Toxicokinetics assessment
  • Two generation repro toxicity
  • Repeated dose toxicity (90 days)
  • Teratogenicity
  • Immunotox, Neurotox
  • Long term (12 months) repeated toxicity study
  • Carcinogenicity study
  • Bird testing
Ecotoxicology
  • Acute daphnia
  • Growth inhibition on Algae
  • Biodegradation
  • Aquatic toxicity with fish
  • Abiotic hydrolysis pH
  • Adsorption/ Desorption screening
  • Acute toxicity on earthworms
  • Long term study on daphnia
  • Long term toxicity on fish
  • Simulation testing – soil, water, sediment
  • Identification of degradation products

Click here for REACH Brochure and REACH Presentation

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