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Eurofins | Advinus is well equipped to offer the entire gamut of analytical studies required for crop protection agents (agrochemicals) and industrial chemicals development to meet the global regulatory requirement. With our fully equipped Analytical R&D laboratory, which includes equipment such as LC-MS/MS, HPLC, GC, GC-MS, we conduct studies in compliance with OECD, OPPTS, EEC, BIS and CIPAC guidelines to enable US-EPA, EU, Brazilian, Mexican, Australian, Canadian, Indian CIB registration and other global submissions.

  • Test item characterization by appearance, purity analysis, IR, NMR and Mass Spectra
  • Method development and validation for active ingredient analysis in technical grade and formulated products
  • Physical and chemical properties of technical grade materials include
    • Active ingredient content (including method development and validation)
    • Color, odor and physical state
    • UV-VIS absorption spectra
    • Melting point & Boiling point
    • Water solubility
    • Solubility in six organic solvents
    • Dissociation constant(s)
    • Hydrolysis as a function of pH
    • Partition coefficient
    • Vapour pressure
    • Relative density/density/specific gravity
    • Accelerated storage stability
    • Flammability (solids)
    • Flash point (liquids)
    • pH
    • Moisture content
    • Loss on drying
    • Oxidation/reduction: Chemical incompatibility
    • Corrosivity
    • Long-term storage stability with corrosion characteristics
    • Aqueous direct photolysis
    • Surface tension
    • Explosive properties
    • Acidity/alkalinity
    • Oxidizing properties
  • Physical and chemical properties of various types of formulated products viz., Water Dispersible Granules (WG) (including blends), Suspension Concentrates (SC), Wettable Powders (WP), Soluble Concentrates (SL), Emulsions in oil/ Water (EW), Emulsifiable Concentrates (EC), Aqueous Suspoemulsions (SE), Aqueous Capsule Suspensions (CS), etc. (studies specific to formulation types would be conducted).
  • Storage stability studies (Accelerated, Real time and Multi-location)
  • Physical and chemical properties of various types of formulated products include the following:
    • Active ingredient content (including method development and validation)
    • Appearance
    • Explosive properties
    • Flash point
    • Relative self-ignition
    • Oxidizing properties
    • Flammability
    • Acidity/Alkalinity/pH
    • Relative density/density/specific gravity
    • Bulk density
    • Wet sieve
    • Dust content
    • Friability & attrition characteristics
    • Flowability
    • Packaging stability
    • Suspensibility
    • Persistent foam
    • Emulsion properties
    • Wettability
    • Degree of dispersion
    • Dispersion stability
    • Corrosivity
    • Viscosity
    • Surface tension
    • Spontaneity of dispersion
    • Pourability
    • Low temperature stability
    • Dilution stability
    • Dissolution rate of water soluble bags

Studies follow the linear way listed below

  • Pre-screening of 5-batches for impurities including 3D screening
  • Impurity identification and structure elucidation in consultation with the sponsor
  • Isolation/synthesis of impurities required for 5-batch analysis
  • GLP analysis of 5-batches using validated analytical methods for active ingredient content and impurities
  • Characterization of 5 commercial batches along with reference standards by UV, IR, NMR, LC-MS/MS and/or GC-MS as applicable

Residue studies and persistence studies are carried out in different matrices viz., plant, plant products, soil and water to meet the regulatory requirement.

  • Eurofins | Advinus has the capability to develop and validate GLP analytical methods as required
  • Capability to conduct residue field trials as per Good Agricultural Practices (GAP) followed by sample analysis as per GLP
  • Persistence studies in plant (field), soil (field and lab) and water (lab)

Eurofins | Advinus is one of the AERB/BARC, Mumbai approved laboratories to conduct studies with radiolabelled compounds and has the approval to handle up to 500 mCi of the labelled material, at any given time.

  • Adsorption / desorption study on soil
  • Rate of degradation on soil (aerobic and anaerobic) and metabolism
  • Rate of degradation on sediments and metabolism
  • Hydrolysis and Photolysis in water
  • High Temperature hydrolysis
  • Soil microorganisms: Nitrogen transformation test
  • Soil microorganisms: Carbon transformation test
  • Mobility in soil
  • Facility and expertise to work with radiolabeled chemicals
  • Method development and validation for analysis of test item concentration in dose formulations
  • Testing stability and homogeneity of the test item in dose formulations
  • Dose confirmation during animal toxicology, eco-toxicology and geno-toxicology studies.
  • Dose formulations include:
    • Dietary admixtures
    • Gavage suspensions / solutions
    • Air inhalation samples
    • Aquarium water
    • Algal medium, etc.

ICP-MS data generation in GLP laboratory

  • Facility to directly aspirate sample solutions in organic solvents
  • Microwave digestion system capable of digesting variety of samples and sample sizes
  • Laboratory with expertise in accurate and precise trace and ultra-trace level analyses
  • Identification and quantification of elemental / metal composition in diversified sample types
  • Toxicokinetic and pharmacokinetic studies requiring elemental analysis
  • Analysis in support of extractables & leachables testing
  • Samples for metal contaminant analysis include:
    • Pharmaceuticals
    • Agrochemical technical materials and other chemicals
    • Crop produce – raw and processed
    • Soils, sediments, etc.
    • Processed food
    • Feed
    • Nutraceuticals
    • Biological matrices, like tissues, blood / plasma, etc.
    • Plastics and other polymers
    • Water
  • Use of reference standards with traceability to international standards