Integrated Chemistry Services
Bench Scale to Commercial Scale  

The team at Eurofins Advinus is able to assist with early phase programs, IND enabling projects, process development and scale-up under non-GMP and GMP compliance for clinical trials and beyond.

Discovery Chemistry - 

• CADD
• Iterative cycles including design of IP free analogues, synthesis and screening testing
• Proficiency in library synthesis and scaffold design/scaffold hopping
• Hit to lead and lead optimization, followed by candidate selection

• Intermediates and building blocks
• Exotic raw materials 
• Metabolites, impurities, reference standards, etc.

• Route screening and selection
• Fit for purpose process development and optimization
• QbD based process development for late phase compounds
• Process safety studies 
• Salt screening and polymorph evaluation
• Potential genotoxic impurity quantification and control 

• Standalone services or Integrated with CMC services 
• Method development and validation
• Impurity isolation, identification (characterization) and profiling 
• Stability studies 

• Rapid piloting and scale-up
• HAZOP studies 
• Non-GMP and GMP manufacturing
• Supply of key RSMs and intermediates
• NCE/API manufacturing 
• Process validation
• Stability studies