Are you looking for bioanalytical/preclinical expertise for complex liposomal formulations?  

Eurofins Advinus has developed sensitive LC-MS/MS based bioanalytical methods for estimation of free, bound / encapsulated and total drug as per FDA and EMA compliance 

Choose Eurofins Advinus as your preferred service provider :

  • To quantify free, bound and total drug levels in biological matrices post administration of liposomal formulations
  • To carry out preclinical in vivo studies
  • For tissue distribution data post IV administration of liposomal formulation from preclinical studies
  • To determine free drug concentration at very low level
  • For potassium leakage and in vitro free drug leakage studies
Eurofins Advinus has the expertise to support you with studies for the following complex formulations and more
Liposomal Doxorubicin
  • Single dose comparative pharmacokinetics and tissue distribution study for liposomal doxorubicin formulation on fibrosarcoma tumor bearing mice
  • LC-MS/MS based bioanalytical methods developed and validated for the determination of free doxorubicin, doxorubicinol, encapsulated and total doxorubicin in mice plasma
  • Total doxorubicin and Doxorubicinol in mice heart, liver, spleen, skin and tumor
  • We also offers comparative in vitro leakage study of Doxorubicin liposomal formulation by LC-MS
  • Regulatory compliance – FDA and EMA
Liposomal Amphotericin B
  • In addition to all the above studies, we offer Comparative in vitro potassium leakage study from human / rat RBC
Carbohydrate Iron Complex formulations
  • Single dose comparative pharmacokinetics and tissue distribution study in SD rats for
    • Iron sucrose formulation
    • Ferric  carboxymaltose formulation
  • ICP-MS based Bioanalytical methods developed and validated for determination of total and transferrin bound iron in rat serum
  • Total iron estimation in the following rat matrices – RBC, Bone marrow, Liver, Heart, Lung, Kidney and Spleen
LC-MS method for quantification of Insulin Glargine in rat plasma
  • We have developed a robust LC-MS method for simultaneous determination of Insulin Glargine and its active metabolite M1 and M2 in rat plasma
  • The precision and accuracy of the developed method has been demonstrated, with sensitivity down to a lower level of 3.0 ng/mL with >5 S/N ratio, and linearity up to 120 ng/mL
  • The method can be adapted for the analysis of human clinical samples
Contact Our Team
Our mailing address is:
#21&22 Phase II, Peenya Industrial Area
Bangalore 560058, India 
Ph:+91-80-28394959 / +91-80-66552700