Understanding pain mechanisms is crucial for developing effective treatments. Our in vivo pain models provide a reliable platform for evaluating novel analgesics, neuropathic pain therapies, and anti-inflammatory drugs.
With validated acute, chronic, neuropathic, and inflammatory pain models, we support pharmaceutical and biotech companies in accelerating drug development.
Acute Pain Models
Acute pain studies help assess the efficacy of pain-relieving compounds by simulating rapid-onset pain responses. Our models include:
- Hot Plate Model (Mice & Rats): Evaluates central pain processing and opioid analgesia.
- Mild Thermal Injury (MTI) Model: Simulates localized thermal pain for assessing analgesic efficacy.
- Tail Immersion Test: Measures pain thresholds through thermal stimuli.
- Brennan Model (Post-Surgical Acute Pain): A validated model for post-operative pain research.
- Tail Flick Test (Mice & Rats): Used to evaluate analgesic drugs affecting spinal reflexes.
- LPS-Induced Inflammatory Pain Model: Mimics systemic inflammatory pain responses.
Chronic: Neuropathic Pain Models
Chronic neuropathic pain arises from nerve damage and is challenging to treat. Our models provide valuable insights into pain pathophysiology and therapeutic interventions:
- Chronic Constrictive Injury (CCI) Model (Sciatic Nerve – Bennett Model): Simulates neuropathic pain caused by nerve compression.
- Spinal Nerve Ligation (SNL) Model (Chung Model – L5/L6): Replicates chronic nerve injury-induced pain.
- Spinal Nerve Ligation (SNL) Model (L5): Models neuropathic pain from localized nerve damage.
- Chemotherapy (Cisplatin)-Induced Peripheral Neuropathic Pain (Rat Model): Evaluates neurotoxicity-related pain relief strategies.
- Osteoarthritis Pain Model (Monosodium Iodoacetate – MIA Induced): Used for studying joint degeneration and pain management.
- Formalin-Induced Persistent Pain Model: A two-phase model for testing long-lasting pain relief strategies.
- Buprenorphine-Induced Tolerance/Withdrawal in Cisplatin-Induced Neuropathic Pain Model: Examines opioid tolerance and withdrawal effects.
Chronic: Inflammatory Pain Models
Chronic inflammatory pain results from conditions like arthritis and tissue injury. Our models include:
- CFA-Induced Inflammatory Pain Model: Simulates chronic inflammatory pain for drug testing.
- dmPGE2-Induced Rat Pain Model: Assesses pain hypersensitivity responses.
- Carrageenan-Induced Rat Pain & Edema Model: Used to study acute inflammation and pain relief mechanisms.
- Formalin-Induced Inflammatory Pain (Mice & Rats): A widely used model for evaluating analgesics targeting inflammatory pain.
Understanding pain mechanisms is crucial for developing effective treatments. Our in vivo pain models provide a reliable platform for evaluating novel analgesics, neuropathic pain therapies, and anti-inflammatory drugs.
Frequently Asked Questions (FAQs)
1. How do I choose the right pain model?
The choice depends on your therapeutic focus. Acute pain models (e.g., hot plate, tail flick) are ideal for fast-acting pain relief studies, while chronic neuropathic pain models (e.g., CCI, SNL) help assess long-term treatments. Inflammatory pain models (e.g., CFA-induced) are best for arthritis-related pain research. Our team can help you select the right model.
2. How relevant are these models to human pain?
Our models closely mimic human pain conditions. Neuropathic pain models replicate nerve injury-induced pain, while inflammatory pain models simulate arthritis and post-surgical pain. These models provide reliable preclinical insights for drug development.
3. Can the models be customized?
Yes, we customize pain induction methods, drug administration routes, and evaluation timelines to fit your study needs. We also offer tailored assessments to meet specific regulatory and research requirements. Talk to our experts to develop the study parameters best suited for your drug.
4. What types of data are collected in these studies?
We measure behavioural responses (paw withdrawal, vocalization), thermal and mechanical sensitivity (hot plate, von Frey), inflammatory markers, and PK/PD correlations to evaluate drug efficacy and mode of action.
5. How long do these studies take?
Acute pain studies take a few days, while chronic pain models may require several weeks to assess long-term effects. Study timelines vary based on endpoints and drug mechanisms. Please get in touch for exact timelines of your project.
Accelerate Your Pain Research Today
Leverage our advanced pain models to drive innovation in pain management. Contact us today to explore how we can support your research goals.