Offered through our partner laboratory, Adgyl Lifesciences
Understanding pain pathways is fundamental to developing effective analgesics and anti-inflammatory therapies. Eurofins Advinus, in collaboration with Adgyl Lifesciences, offers a comprehensive suite of in vivo pain models designed to evaluate drug efficacy across acute, chronic, neuropathic, and inflammatory pain conditions.
These validated models help pharmaceutical and biotech companies generate predictive, actionable data during preclinical development—supporting better decision-making and faster progress to clinical stages.
Acute Pain Models
Acute pain models replicate rapid-onset pain conditions to evaluate short-acting analgesics and central pain mechanisms. Key models include:
- Hot Plate Model (Mice & Rats): Assesses centrally mediated nociception and opioid response.
- Mild Thermal Injury (MTI) Model: Mimics localized thermal pain, ideal for thermal analgesic evaluation.
- Tail Immersion Test: Measures pain threshold based on response to heat.
- Brennan Model (Post-Surgical Pain): A validated post-operative pain model for assessing surgical analgesics.
- Tail Flick Test (Mice & Rats): Evaluates drugs affecting spinal reflexes and pain latency.
- LPS-Induced Inflammatory Pain Model: Simulates systemic inflammatory pain for broader therapeutic screening.
Chronic: Neuropathic Pain Models
Neuropathic pain—caused by nerve damage or dysfunction—requires specialized preclinical models. Offered via Adgyl Lifesciences, our chronic pain models support mechanistic and pharmacodynamic studies, including:
- Chronic Constrictive Injury (CCI, Sciatic Nerve – Bennett Model): Simulates compression-induced nerve injury.
- Spinal Nerve Ligation (SNL – Chung Model, L5/L6): A standard for chronic nerve injury and central sensitization.
- Spinal Nerve Ligation (L5): Focuses on localized nerve trauma and related pain behaviors.
- Cisplatin-Induced Peripheral Neuropathy (Rat): Evaluates therapies targeting chemotherapy-induced neurotoxicity.
- Osteoarthritis Pain Model (MIA-Induced): Used for evaluating analgesics in joint degeneration.
- Formalin-Induced Persistent Pain: A biphasic model for assessing long-lasting analgesic effects.
- Buprenorphine-Induced Tolerance/Withdrawal in Cisplatin Model: Assesses opioid tolerance and withdrawal in neuropathic conditions.
Chronic: Inflammatory Pain Models
Chronic inflammatory pain—often associated with arthritis or soft tissue damage—can be effectively modeled using:
- CFA-Induced Inflammatory Pain Model: Replicates persistent inflammatory pain.
- dmPGE2-Induced Rat Pain Model: Evaluates pain hypersensitivity and prostaglandin-related pathways.
- Carrageenan-Induced Pain & Edema Model: A rapid, reversible model for acute inflammation and analgesia.
- Formalin-Induced Inflammatory Pain (Mice & Rats): Commonly used to screen anti-inflammatory and analgesic drugs.
Why Choose Our In Vivo Pain Models?
- Clinically Relevant Models: Replicating human-like pain conditions for improved translational outcomes
- Full Spectrum Coverage: From acute thermal pain to chronic neuropathy and inflammatory disorders
- Customized Study Designs: Tailored protocols, dosing regimens, and endpoints to match your drug’s mechanism
- Expert Scientific Support: Guidance throughout the study—from model selection to data interpretation
Frequently Asked Questions (FAQs)
How do I choose the right pain model for my study?
The model choice depends on the nature of your compound and its intended indication. For example, hot plate and tail flick tests are ideal for acute pain, while CCI and SNL models support chronic and neuropathic pain research. Our team will help you select the optimal model based on your research goals.
How translatable are these models to human conditions?
These models are extensively validated and replicate the underlying pathophysiology of human pain, including inflammatory, post-operative, and chemotherapy-induced pain—enhancing clinical predictability.
Can the models and protocols be customized?
Yes, we offer complete flexibility in pain induction, treatment regimen, evaluation windows, and endpoint assessments to meet your study needs and regulatory goals.
What types of data can I expect from a pain study?
Deliverables include behavioral scoring (withdrawal latency, vocalization), thermal/mechanical thresholds (e.g., hot plate, von Frey), biomarker analysis, histopathology, and PK/PD correlation—all compiled into a comprehensive final report.
What are the typical timelines for these studies?
Acute pain models can be completed within days, while chronic pain models may span several weeks. Timelines depend on study objectives, endpoints, and treatment schedules. Contact us for a customized project timeline.
Accelerate Your Pain Research Today
With access to industry-validated pain models through Adgyl Lifesciences and the scientific oversight of Eurofins Advinus, you can confidently advance your preclinical pain research with actionable data and regulatory readiness.
Get in touch with our team today to discuss how we can support your pain management program.