Precision Insights for Topical and Transdermal Product Evaluation
Eurofins Advinus offers high-quality in vitro skin absorption studies using the Franz diffusion cell method, supporting the regulatory and R&D needs of agrochemical, pharmaceutical, cosmetic, and chemical manufacturers. With robust experience and a commitment to compliance, our studies are conducted under GLP standards, ensuring global acceptance of your data for regulatory submissions.
Whether your compound is radiolabelled or non-radiolabelled (cold), our advanced analytical capabilities and experienced team ensure accurate, reproducible, and reliable assessment of percutaneous absorption and dermal bioavailability.
Why Choose Eurofins Advinus?
- Extensive Expertise in Franz Cell Assays
- Capabilities for Radiolabelled and Cold Compound Testing
- Advanced Analytics: HPLC, GC, LC-MS/MS, Liquid Scintillation Counting
- GLP-Compliant Protocols with Global Regulatory Alignment (OECD 428, etc.)
- Experienced Team with Proven Regulatory Study Submissions Worldwide
Applications of In Vitro Skin Absorption Studies
- Safety and risk assessment of dermal exposure
- Determining systemic absorption from dermal products
- Comparative dermal bioavailability (e.g., formulations, concentrations)
- Regulatory submissions for agrochemicals, cosmetics, pharmaceuticals, and chemicals
- Product development support for transdermal or topical formulations
Our Technical Capabilities
- Franz Diffusion Cell Method using human or animal skin
- Radiolabelled Studies (14C-compounds) supported by:
- Liquid Scintillation Counting (LSC)
- Radiochromatography
- Cold Compound Studies supported by:
- HPLC
- GC
- LC-MS/MS
- Custom protocol development based on your product and regulatory needs
Frequently Asked Questions (FAQs)
The Franz diffusion cell method is a gold-standard in vitro technique used to evaluate how much of a compound penetrates through the skin, helping assess the potential for dermal absorption and systemic exposure.
We assess both radiolabelled and cold (non-radiolabelled) compounds. Our team has experience working with agrochemicals, pharmaceuticals, cosmetics, biocides, and industrial chemicals.
Yes. Our studies are conducted under GLP conditions and in accordance with international guidelines such as OECD Test Guideline 428, ensuring acceptance by global regulatory bodies.
We offer studies using human skin (when ethically sourced and available) as well as animal skin models, depending on regulatory requirements and compound characteristics.
Absolutely. Our in-house QA team ensures all data meet compliance standards, and our technical documentation supports submission to authorities like EPA, ECHA, OECD, and national regulators worldwide.
Partner with Eurofins Advinus for Trusted Skin Absorption Testing
Whether you're optimizing a new topical formulation or completing a pesticide registration package, we offer scientific rigor, regulatory expertise, and unmatched data integrity.
