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Drug Metabolism and Pharmacokinetics (DMPK)
The DMPK department has broad capabilities to support various drug discovery and drug development studies. Advinus adopts a parallel and iterative testing mode that is concurrent with the lead optimization process to ensure that compounds optimized for activity and potency are “druggable”. We have an unparalleled combination of experience and laboratory resources.
Services
In vitro studies
- CYP inhibition - Fluorescence and LCMS
- CYP reaction phenotyping
- Stability in microsomes and hepatocytes
- Solubility
- Metabolite fingerprinting
- CaCO-2 & MDCK permeability
- Plasma Protein Binding
In vivo studies
- PK studies (Mouse, Rat and Dog)
- Dose proportionality
- Formulation evaluation
- Version/ Salt selection
- 14C Mass balance and tissue distribution
- Enterohepatic recirculation
- Metabolite profiling

