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Journal Article/Patents

“Histopathology Evaluation and Peer Review for Nonclinical Studies: Raw Data Compliance to GLP Quality Systems”, Settiagounder, Natesan, Journal of Regulatory Science, 2017, 5, 2, 45-55

“Histopathology Peer Review for Nonclinical Studies – GLP Processes and Conditions”, Settiagounder, Natesan, Journal of Regulatory Science, 2017, 5, 2, 56-66

“Rational design, synthesis, and structure-activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors”, Basu, Sujay; Prathipati, Philip; Thorat, Sachin; Ansari, Shariq; Patel, Meena; Jain, Vaibhav; Jinugu, Ramana R.; Niranjan, Sanjay; De, Siddhartha; Reddy, Satyanarayana, Bioorganic & Medicinal Chemistry, 2016, DOI: 10.1016/j.bmc.2016.10.012

“Identification, charecterization and quantification of process related impurities in azimsulfuron technical”, Venkatesh, M. Prabhu; Pardhasaradhi, V.; Dhayanithi, V.; Avinash, Mane; Palimkar, S.; Subhash, R. Kadam; Mohan, Hindupur Rama, Chemical Science Transactions, 2016, 5, 1, 41-55, DOI: 10.7598/cst2016.1132

“Impact of APCI ionization source in liquid chromatography tandem mass spectrometry based tissue distribution studies”, Khatal Laxman; Gaur Ashwani; Naphade Ashish; Kandikere Vishwottam; Mookhtiar Kasim, Biomedical chromatography : BMC, 2016, 30, 10, 1676-85

“Assessment of in vitro metabolic stability, plasma protein binding, and pharmacokinetics of E- and Z-guggulsterone in rat”, Chhonker Yashpal S; Chandasana Hardik; Prasad Yarra Durga; Laxman Tulsankar Sachin; Bhatta Rabi S; Chhonker Yashpal S; Chandasana Hardik; Laxman Tulsankar Sachin; Bhatta Rabi S; Mukkavilli Rao; Vangala Subrahmanyam; Mukkavilli Rao, Drug testing and analysis, 2016, 8, 9, 966-75

“Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats”, Kamble Bhagyashree;  Gupta Ankur; Moothedath Ismail; Duraiswamy B;  Khatal Laxman; Janrao Shirish; Jadhav Amol, Chemico-biological interactions, 2016,  24530-8

“Efficient synthesis of β-lactam containing α-hydroxy phosphonates using tartaric acid and fumaric acid as mild catalysts”, Vangala, Vijaya Bhaskar; Pati, Hari N., Synthetic Communications 2016, 46, 4, 374-378, DOI:10.1080/00397911.2016.1139722

“Synthesis and antiproliferative properties of isoxazole analogs containing dibenzosuberane moiety”,  Moger, Manjunath; Pradhan, Ashok; Singh, Apoorva; Govindaraju, Darshan Raj Chenna; Hindupur, Rama Mohan; Pati, Hari N., Medicinal Chemistry Research 2016, 25, 3, 449-455, DOI:10.1007/s00044-015-1497-3

“Protective role of liv.52 on the toxicity of acetaminophen during embryogenesis in Wistar rats”, Santhosh Kumar, D.P., Deecaraman, M., Vijayalaksmi, M., Ramesh Edamula, Krishnappa, H., Latha, M. and GeethaRao, G, International Journal of Current Research, 2015, 7, 5, 16392-16401, ISSN:0975-833X

“Pharmacological and Biological Activities of Benzazepines: An Overview”, Shah, Jigar H.; Hindupur, Rama M.; Pati, Hari N., Current Bioactive Compounds, 2015, 11, 3, 170-188, DOI:10.2174/1573407211666150910202200

“Aminothiazoles: Hit to lead development to identify antileishmanial agents”, Bhuniya, Debnath; Mukkavilli, Rao; Shivahare, Rahul; Launay, Delphine; Dere, Ravindra T.; Deshpande, Anil; Verma, Aditya; Vishwakarma, Preeti; Moger, Manjunath; Pradhan, Ashok; et al, European Journal of Medicinal Chemistry (2015), 102, 582-593, DOI:10.1016/j.ejmech.2015.08.013

“Efficient and Scalable Process for Synthesis of 5-Nitro-7-azaindole”, Bhat, Prasanna V.; Dere, Ravindra T.; Ravikumar, S.; Hindupur, Rama Mohan; Pati, Hari N., Organic Process Research & Development, 2015, 19, 9, 1282-1285., DOI:10.1021/acs.oprd.5b00181

“Preparation of substituted heterobicyclic compounds, compositions and medicinal applications thereof”, Thakkar, Mahesh; Koul, Summon; Bhuniya, Debnath; Mookhtiar, Kasim, Indian Pat. Appl., 2015, IN 2012CH01573 A 20150710

“Chemistry of macrocyclic β-lactam: an overveiw”, Vangala, Vijaya Bhaskar; Maddani, Mahagundappa Rachappa; Hindupur, Rama Mohan; Pati, Hari Narayan,  Heterocycles, 2015, 91, 4, 701-717, DOI:10.3987/REV-14-812

“Noscapine recirculates enterohepatically and induces self-clearance”, Mukkavilli, Rao; Gundala, Sushma R.; Yang, Chunhua; Jadhav, Gajanan R.; Vangala, Subrahmanyam; Reid, Michelle D.; Aneja, Ritu, European Journal of Pharmaceutical Sciences, 2015, 77, 90-99, DOI:10.1016/j.ejps.2015.05.026

“Identification and Synthesis of Major Impurities Formed During the Synthesis of Trifloxystrobin and Kresoxim- methyl Fungicides”, Kamaraj, Pasumpon; Antao, Nakita; Singh, Apoorva; Satam, Vijay; Kadam, Subhash; Prabhu, Venkatesh M.; Hindupur, Rama Mohan; Pati, Hari N., Letters in Organic Chemistry, 2015, 12, 5, 306-310, DOI:10.2174/1570178612666150318002831

“Preparation of substituted heterobicyclic compounds, compositions and medicinal applications thereof as Btk inhibitors”,  Thakkar, Mahesh; Koul, Summon; Bhuniya, Debnath; Mookhtiar, Kasim; Kurhade, Santosh; Munot, Yogesh; Mengawade, Tanaji; Kulkarni, Bheemashankar A., From U.S. Pat. Appl. Publ., 2015, US 20150064196 A1 20150305

“A process for the preparation of fluoxastrobin”, Hindupur, Rama Mohan; Mane, Avinash Sheshrao; Balakrishnan, Sankar; Pawar, Jivan Dhanraj; Maddani, Mahagundappa Rachappa; Wadhwa, Sandeep; Prasad, Vic, U.S. Pat. Appl. Publ., 2015, US 20150011753 A1 20150108

“Assessment of in vitro metabolic stability, plasma protein binding, and pharmacokinetics of E- and Z- guggulsterone in rat”, Chhonker Yashpal S; Chandasana Hardik; Prasad Yarra Durga; Laxman Tulsankar Sachin; Bhatta Rabi S; Chhonker Yashpal S; Chandasana Hardik; Laxman Tulsankar Sachin; Bhatta Rabi S; Mukkavilli Rao; et al, Drug testing and analysis, 2015

“In vitro anticancer activity of methyl caffeate isolated from Solanum torvum Swartz. Fruit”, Balachandran C; Emi N; Yamamoto Y; Inaguma Yoko; Okamoto Akinao; Arun Y; Perumal P T; Ahilan B; Ignacimuthu S; Sangeetha B; et al, Chemico-biological interactions, 2015, 24281-90

“Reversibility of dopamine receptor antagonist-induced hyperprolactinemia and associated histological changes in Tg RasH2 wild-type mice”, Krishna Gopala; Gopalakrishnan Gopa; Goel Saryu; Ganiger Shivaputhrappa; Kannan Kamala, Reproductive toxicology, 2015, 5873-8

“Noscapine recirculates enterohepatically and induces self-clearance”, Mukkavilli Rao; Gundala Sushma R; Yang Chunhua; Jadhav Gajanan R; Vangala Subrahmanyam; Reid Michelle D; Aneja Ritu, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences , 2015, 7790-9

“Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer”, Yang Chunhua; Gundala Sushma Reddy; Aneja Ritu; Mukkavilli Rao; Vangala Subrahmanyam; Reid Michelle D., Carcinogenesis, 2015, 36, 6, 656-65

“A convenient and mild one pot synthesis of cyclopentenone derivatives”, Moger, Manjunath; Pradhan, Ashok Kumar; Hindupur, Rama Mohan; Pati, Hari N., Tetrahedron Letters,  2014, 55, 16, 2675-2678, DOI:10.1016/j.tetlet.2014.03.038

“A flavonoid isolated from Streptomyces sp. (ERINLG-4) induces apoptosis in human lung cancer A549 cells through p53 and cytochrome c release caspase dependant pathway”, Balachandran C; Ignacimuthu S; Balakrishna K; Sangeetha B; Duraipandiyan V; Raj M Karunai; Parthasarathy K; Al-Dhabi N A; Arasu M Valan; Arulmozhi N M, Chemico-biological interactions, 2014, 22424-35

“An efficient synthesis of new β-lactam substituted 1,2,3-triazole via CuI-NBS mediated Click Chemistry”, Vangala, Vijaya Bhaskar; Mane, Avinash S.; Hindupur, Rama Mohan; Pati, Hari N., Chemistry Journal 2014, 4, 1, 8-12, 5

“Cholesterol homeostasis: lipoproteins in action”, Malashetty, Vijaykumar B., Asian Journal of Science and Technology, 2014, 5, 7, 400-404

“Design, synthesis, ADME characterization and antileishmanial evaluation of novel substituted quinoline analogs”, Gopinath, Vadiraj S.; Rao, Mukkavilli; Shivahare, Rahul; Vishwakarma, Preeti; Ghose, Sweta; Pradhan, Ashok; Hindupur, Ramamohan; Sarma, Koushik Das; Gupta, Suman; Puri, Sunil K.; et al, Bioorganic & Medicinal Chemistry Letters, 2014, 24, 9, 2046-2052, DOI:10.1016/j.bmcl.2014.03.065

“Development and validation of a liquid chromatographic enantiomer separation method for the estimation of (S)-enantiomer in sitagliptin”, Mone, Mahesh Kumar; Jain, Payal; Kurhade, Santosh; Sonune, Dnyaneshwar P.; Kaduskar, Rahul D., International Journal of Pharmaceutical Sciences and Research, 2014, 5, 6, 2382-2386, DOI:10.13040/IJPSR.0975-8232.5(6).2382-86

“Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract”, Gundala Sushma R; Yang Chunhua; Aneja Ritu; Mukkavilli Rao; Vangala Subrahmanyam; Yadav Pooja; Tandon Vibha; Prakash Satya, Carcinogenesis, 2014, 35, 6, 1320-9

“Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis”, Gundala Sushma Reddy; Yang Chunhua; Paranjpe Rutugandha; Brahmbhatt Meera; Pannu Vaishali; Cheng Alice; Mukkavilli Rao; Reid Michelle D; Aneja Ritu, Toxicology and applied pharmacology, 2014, 280, 1, 86-96

“In vitro metabolism, disposition, preclinical pharmacokinetics and prediction of human pharmacokinetics of DNDI-VL-2098, a potential oral treatment for Visceral Leishmaniasis”, Mukkavilli, Rao; Pinjari, Jakir; Patel, Bhavesh; Sengottuvelan, Shankar; Mondal, Subodh; Gadekar, Ajit; Verma, Manas; Patel, Jignesh; Pothuri, Lavanya; Chandrashekar, Gopu; et al, European Journal of Pharmaceutical Sciences, 2014, 65, 147-155, DOI:10.1016/j.ejps.2014.09.006

 

“Modulation of cytochrome P450 metabolism and transport across intestinal epithelial barrier by ginger biophenolics”, Mukkavilli, Rao; Gundala, Sushma R.; Yang, Chunhua; Donthamsetty, Shashikiran; Cantuaria, Guilherme; Jadhav, Gajanan R.; Vangala, Subrahmanyam; Reid, Michelle D.; Aneja, Ritu, PLoS One, 2014, 9, 9, DOI:10.1371/journal.pone.0108386

“Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity”, Henary Maged; Owens Eric A; Nagaraju Mulpuri; Hamelberg Donald; Narayana Lakshminarayana; Yadav Yogesh; Ahad Shazia; Panda Dulal; Gundala Sushma R; Sharma Vibhuti; et al, Biochemical pharmacology, 2014, 92, 2, 192-205

“Preparation of spirocyclic compounds as DGAT1 inhibitors, compositions containing same, and medicinal applications thereof”, Koul, Summon; Bhuniya, Debnath; Mookhtiar, Kasim; Bhosale, Sandeep; Kurhade, Suresh; Naik, Keshav; Velayutham, Ravikumar; Salunkhe, Videsh, PCT Int. Appl., 2014, WO 2014054053 A1 20140410

“Preparation of substituted fused tricyclic compounds as JAK kinase inhibitors, compositions and medicinal applications thereof”, Barawkar, Dinesh; Bende, Tanushree; Zahler, Robert; Bandyopadhyay, Anish, Indian Pat. Appl., 2014, IN 2011CH00891 A 20140214

“Preparation of tricyclic compounds as JAK modulators for treatment of JAK-associated diseases”, Barawkar, Dinesh; Bandyopadhyay, Anish; Zahler, Robert; Sarangthem, Robindro; Waman, Yogesh; Bonagiri, Rajesh; Jadhav, Dilip; Mukhopadhyay, Partha, PCT Int. Appl., 2014, WO 2014045305 A1 20140327

“Synthesis and antimicrobial evaluation of some substituted-3-aryl-2,3,4,5,6,7-hexahydro-1H-inden-1-one”, Moger, Manjunath; Govndraju, Darshan Raj C.; Hindupur, Rama Mohan; Pati, Hari Narayan, Chemical Science Transactions, 2014, 3, 4, 1483-1487, 5 pp.,  DOI:10.7598/cst2014.867

“Synthesis and antimicrobial properties of 1,3,4-oxadiazole analogs containing dibenzosuberane moiety”, Moger, Manjunath; Satam, Vijay; Govindaraju, Darshan Raj C.; Paniraj, A. S.; Gopinath, Vadiraj S.; Hindupur, Rama Mohan; Pati, Hari N., Journal of the Brazilian Chemical Society, 2014, 25, 1, 104-111, DOI:10.5935/0103-5053.20130275

“Synthesis of L-azaisotryptophan and its analogs: a general access to new 2-substituted azaindoles”, Kurhade, Santosh; Rajopadhyay, Vandana; Avaragolla, Satheesh Veerappa; Koul, Summon; Ramaiah, Parimi Atchuta; Bhuniya, Debnath, Tetrahedron Letters, 2014, 55, 15, 2415-2419, DOI:10.1016/j.tetlet.2014.02.125

“Synthesis of substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylate from a common acyclic precursor employing C-formylation strategy”, Khose, Goraksha; Shinde, Shailesh; Panmand, Anil; Kulkarni, Ravibhushan; Munot, Yogesh; Bandyopadhyay, Anish; Barawkar, Dinesh; Patil, Santoshkumar N., Tetrahedron Letters, 2014, 55, 16, 2671-2674, DOI:10.1016/j.tetlet.2014.03.039

“An Improved Kilogram-Scale Synthesis of 2-Bromo-4-nitro-1H-imidazole: A Key Building Block of Nitroimidazole Drugs”, Pedada, Srinivasa Rao; Satam, Vijay S.; Tambade, Pawan J.; Kandadai, Srinivas A.; Hindupur, Rama Mohan; Pati, Hari N.; Launay, Delphine; Martin, Denis, Organic Process Research & Development, 2013, 17, 9, 1149-1155, DOI:10.1021/op400095f

“Design, synthesis and biological evaluation of 2-substituted quinolines as potential antileishmanial agents”, Gopinath, Vadiraj S.; Pinjari, Jakir; Dere, Ravindra T.; Verma, Aditya; Vishwakarma, Preeti; Shivahare, Rahul; Moger, Manjunath; Kumar Goud, Palusa Sanath; Ramanathan, Vikram; Bose, Prosenjit; et al, European Journal of Medicinal Chemistry, 2013, 69, 527-536, DOI:10.1016/j.ejmech.2013.08.028

“Highly efficient one-pot amination of carboxylate-substituted nitrogen-containing heteroaryl chlorides via Staudinger reaction”, Kandalkar, Sachin R.; Kaduskar, Rahul D.; Ramaiah, Parimi Atchuta; Barawkar, Dinesh A.; Bhuniya, Debnath; Deshpande, Anil M., Tetrahedron Letters, 2013, 54, 5, 414-418., DOI:10.1016/j.tetlet.2012.11.027

“Isolation, characterization of degradation products of sitagliptin and development of validated stability-indicating HPLC assay method for sitagliptin API and tablets”,  Sonune, Dnyaneshwar P.; Mone, Mahesh Kumar, International Journal of Pharmaceutical Sciences and Research, 2013, 4, 9, 3494-3503, 10,  DOI:10.13040/IJPSR.0975-8232.4(9).3494-03

“Preparation of amide compounds as FAAH inhibitors, compositions and applications thereof”, Kharul, Rajemdra; Bhuniya, Debnath; Mookhtiar, Kasim; Singh, Umesh; Hazare, Atul; Patil, Satish; Datrange, Laxmikant; Thakkar, Mahesh, Indian Pat. Appl., 2013, IN 2011CH03308 A 20130621

“Preparation of amide compounds as FAAH inhibitors, compositions and applications thereof”, Kharul, Rajendra; Bhuniya, Debnath; Mookhtiar, Kasim A.; Singh, Umesh; Hazare, Atul; Patil, Satish; Datrange, Laxmikant; Thakkar, Mahesh, PCT Int. Appl., 2013, WO 2013042139 A1 20130328

“Preparation of fused tricyclic compounds as therapeutic adenosine receptor antagonists”, Barawkar, Dinesh; Basu, Sujay; Ramdas, Vidya, Indian Pat. Appl., 2013, IN 2010CH02808 A 20130329

“Preparation of substituted heterobicyclic compounds, compositions and medicinal applications thereof”, Thakkar, Mahesh; Koul, Summon; Bhuniya, Debnath; Singh, Umesh, PCT Int. Appl., 2013, WO 2013157021 A1 20131024

“Preparation of substituted heterobicyclic compounds, compositions and medicinal applications thereof”, Thakkar, Mahesh; Koul, Summon; Bhuniya, Debnath; Mookhtiar, Kasim; Kurhade, Santosh; Munot, Yogesh, PCT Int. Appl., 2013, WO 2013157022 A1 20131024

“Stereo-controlled total syntheses of ieodomycins A and B using D-glucose based chiral pool approach”, Salunkhe, Videsh T.; Bhosale, Sandeep; Punde, Prasad; Bhuniya, Debnath; Koul, Summon, Tetrahedron Letters, 2013, 54, 20, 2489-2491, DOI:10.1016/j.tetlet.2013.03.002

“Synthesis of a sex pheromone of the longtailed mealybug, Pseudococcus longispinus”, Kurhade, Suresh E.; Siddaiah, V.; Bhuniya, Debnath; Reddy, D. Srinivasa, Synthesis, 2013, 45, 12, 1689-1692, DOI:10.1055/s-0033-1338450

“Synthesis of new binol based [1+1] macrocyclic chiral manganese(III) Schiff bases as catalysts for asymmetric epoxidation”, Suresh, Paulsamy; Srimurugan, Sankareswaran; Dere, Ravindra T.; Ragavan, R. Venkat; Gopinath, Vadiraj Suphala, Tetrahedron: Asymmetry, 2013,  24, 11, 669-676, DOI:10.1016/j.tetasy.2013.04.017

“Unprecedented N→C[1,4] Boc migration: synthesis of 3-carboxyl functionalized 7-azaindolo[2,1-c][1,4]benzoxazine ring system”, Kurhade, Santosh; Ramaiah, Parimi Atchuta; Prathipati, Philip; Bhuniya, Debnath, Tetrahedron, 2013, 69, 4, 1354-1362, DOI:10.1016/j.tet.2012.11.073

“Acetamide compounds as glucokinase modulators and their preparation and use for treatment and prevention of glucokinase-mediated diseases”, Kurhade, Santosh; Kandalkar, Sachin; Kaduskar, Rahul; Kobal, Balasaheb; Naik, Keshav; Dave, Bhavesh; Deshpande, Anil; Bhuniya, Debnath; Palle, Venkata Poornapragnacharyulu, PCT Int. Appl., 2012, WO 2012020357 A1 20120216

“Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors”, Basu, Sujay; Prasad, Uppuleti Viplava; Barawkar, Dinesh A.; De, Siddhartha; Palle, Venkata P.; Menon, Suraj; Patel, Meena; Thorat, Sachin; Singh, Umesh P.; Sarma, Koushik Das; et al, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 8, 2843-2849, DOI:10.1016/j.bmcl.2012.02.070

“Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase”, Barawkar, Dinesh A.; Bandyopadhyay, Anish; Deshpande, Anil; Koul, Summon; Kandalkar, Sachin; Patil, Pradeep; Khose, Goraksha; Vyas, Samir; Mone, Mahesh; Bhosale, Shubhangi; et al, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 13, 4341-4347, DOI:10.1016/j.bmcl.2012.05.020

“Inverse kinetic isotope effect in Magtrieve mediated oxidation or deoximation of benzaldoxime: mechanistic implication”, Bhosale, Sandeep; Sonune, Dnyaneshwar P.; Prasad, Uppuleti Viplava; Bhuniya, Debnath, Tetrahedron Letters,  2012, 53, 14, 1794-1797, DOI:10.1016/j.tetlet.2012.01.111

“Luseogliflozin: SGLT2 inhibitor treatment of diabetes”, Tiwari, A., Drugs of the Future, 2012, 37, 9, 637-643, DOI:10.1358/dof.2012.37.9.1848191

“Preparation of acetamide compounds as glucokinase activators, their process and medicinal applications”, Deshpande, Anil; Dave, Bhavesh; Kurhade, Santosh; Kobal, Balasaheb; Naik, Keshav; Kandalkar, Sachin; Bhuniya, Debnath; Palle, Venkata Poornapragnacharyulu, Eur. Pat. Appl., 2012, EP 2402327 A1 20120104

“Preparation of acetamide derivatives as glucokinase activators”, Bhuniya, Debnath; Bhosale, Sandeep Bhausaheb; De, Siddhartha; Palle, Venkata Poornapragnacharyulu, Indian Pat. Appl., 2012, IN 2007CH02266 A 20120921

“Preparation of acetamide derivatives as glucokinase activators”, Bhuniya, Debnath; Deshpande, Anil; Kandalkar, Sachin; Kobal, Balasaheb; Kurhade, Santosh; Vyavahare, Vinod; Kaduskar, Rahul, From U.S. Pat. Appl. Publ. (2012), US 20120214735 A1 20120823

“Preparation of fused pyrimidine compounds as therapeutic adenosine receptor antagonist”, Palle, Venkata; Basu, Sujay; Waman, Yogesh; Ramadas, Vidya; Barawkar, Dinesh, From Indian Pat. Appl., 2012, IN 2008CH00746 A 20120629

“Preparation of fused tricyclic compounds as therapeutic adenosine receptor antagonist”, Barawkar, Dinesh; Basu, Sujay; Ramdas, Vidya; Naykodi, Minakshi; Patel, Meena; Shejul, Yogesh; Thorat, Sachin; Panmand, Anil, PCT Int. Appl., 2012, WO 2012038980 A2 20120329

“Preparation of purine compounds as prodrugs of A2B adenosine receptor antagonists”, Barawkar, Dinesh; Basu, Sujay; Ramdas, Vidya; Palle, Venkata Poornapragnacharyulu; Waman, Yogesh; Patel, Meena; Panmand, Anil, Indian Pat. Appl., 2012, IN 2010CH02671 A 20120713

“Preparation of purine compounds as prodrugs of A2B adenosine receptor antagonists”, Barawkar, Dinesh; Basu, Sujay; Ramdas, Vidya; Palle, Venkata Poornapragnacharyulu; Waman, Yogesh; Patel, Meena; Panmand, Anil, PCT Int. Appl., 2012, WO 2012035548 A1 20120322

“Preparation of substituted fused pyrimidine compounds as adenosine receptor antagonists”,  Palle, Venkata; Ramdas, Vidya; Barawkar, Dinesh; Basu, Sujay; Koul, Summon; Waman, Yogesh, From Indian Pat. Appl., 2012, IN 2009CH00571 A 20120413

“Preparation of substituted fused tricyclic compounds as JAK kinase inhibitors, compositions and medicinal applications thereof”, Barawkar, Dinesh; Bende, Tanushree; Zahler, Robert; Bandyopadhyay, Anish; Sarangthem, Robindro Singh; Doshi, Jignesh; Waman, Yogesh; Jadhav, Rushikesh; Singh, Umesh Prasad, PCT Int. Appl., 2012, WO 2012127506 A1 20120927

“Substituted fused pyrimidine compounds, their preparation and therapeutic uses thereof”, Ramdas, Vidya; Koul, Summon; Basu, Sujay; Waman, Yogesh; Shejul, Yogesh; Barawkar, Dinesh; Palle, Venkata, Indian Pat. Appl., 2012, IN 2009CH02720 A 20120420

“A phosphine-mediated synthesis of 1,4-oxazepine- and 1,5-oxazocine-based sugar hybrids from deoxysugar azides”, Kurhade, Suresh E.; Salunkhe, Videsh T.; Siddaiah, V.; Bhuniya, Debnath; Reddy, D. Srinivasa, Synthesis, 2011, 21, 3523-3529, DOI:10.1055/s-0030-1260218

“An enantiospecific route to (+)-(1R,3S)-cis-chrysanthemic acid from (-)-D-pantolactone”, Hajare, Atul K.; Datrange, Laxmikant S.; Murthy, Y. L. N.; Bhuniya, Debnath; Reddy, D. Srinivasa, Synthesis, 2011, 7, 1067-1070, DOI:10.1055/s-0030-1258451

 

 

 

“Degradation Studies of Triprolidine: Isolation, Characterization of Oxidative Degradation Products and Development of A Validated Stability Indicating Uhplc Method”, Mone, Mahesh Kumar; Chandrasekhar, K. B.; Vyas, Samir, From Journal of Liquid Chromatography & Related Technologies, 2011, 34, 8, 652-669, DOI:10.1080/10826076.2011.558651

 

“Development of liquid chromatographic enantiomer separation methods and validation for the estimation of (R)-enantiomer in eslicarbazepine acetate”, Mone, Mahesh Kumar; Chandrasekhar, K. B., Journal of Pharmaceutical and Biomedical Analysis, 2011, 54, 1, 248-251, DOI:10.1016/j.jpba.2010.08.015

“Discovery of a potent and selective small molecule hGPR91 antagonist”, Bhuniya, Debnath; Umrani, Dhananjay; Dave, Bhavesh; Salunke, Deepak; Kukreja, Gagan; Gundu, Jayasagar; Naykodi, Minakshi; Shaikh, Nadim S.; Shitole, Prasad; Kurhade, Santosh; et al, Bioorganic & Medicinal Chemistry Letters,  2011, 21, 12, 3596-3602, DOI:10.1016/j.bmcl.2011.04.091

“Evaluation of Generic Gradients, Sample Pooling and MS Detection as Chiral Resolution Screening Strategies on Diverse Chiral Stationary Phases”, Mone, Mahesh Kumar; Chandrasekhar, K. B., Chromatographia, 2011, 73, 9-10, 985-992, DOI:10.1007/s10337-011-1980-z

“Fused nitrogen heterocyclic compounds as glucokinase modulators and their process for preparation and use in the treatment of glucokinase-mediated diseases”, Dave, Bhavesh; Deshpande, Anil; Kurhade, Santosh; Kobal, Balasaheb; Bhuniya, Debnath; Palle, Venkata, PCT Int. Appl., 2011, WO 2011080755 A1 20110707

“Potent and Selective Inhibitors of Long Chain L-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats”, Barawkar, Dinesh A.; Meru, Ashwin; Bandyopadhyay, Anish; Banerjee, Abir; Deshpande, Anil M.; Athare, Chandrashekhar; Koduru, Chandrasekhar; Khose, Goraksha; Gundu, Jayasagar; Mahajan, Koshu; et al, ACS Medicinal Chemistry Letters, 2011, 2, 12, 919-923, DOI:10.1021/ml2001938

“Preparation of benzamide compounds as glucokinase activators and their pharmaceutical application”,

Deshpande, Anil; Kandalkar, Sachin; Naik, Keshav; Dave, Bhavesh; Bhuniya, Debnath; Palle, Venkata, PCT Int. Appl., 2011, WO 2011095997 A1 20110811

“Regulated bioanalysis: an Indian perspective on harmonization efforts”, Ramanathan, Vikram K.; Vachharajani, Nimish N., Bioanalysis, 2011, 3, 7, 713-716, DOI:10.4155/bio.11.14

“Stereo-conserved synthesis of syn-diarylheptanoids, active principles of Zingiber, starting from D-glucose”, Bhosale, Sandeep; Vyavahare, Vinod P.; Prasad, Uppuleti Viplava; Palle, Venkata P.; Bhuniya, Debnath, Tetrahedron Letters, 2011, 52, 26, 3397-3400, DOI:10.1016/j.tetlet.2011.04.097

 

 

“Substituted fused pyrimidine compounds, its preparation and uses thereof”, Ramdas, Vidya; Koul, Summon; Basu, Sujay; Waman, Yogesh; Shejul, Yogesh; Barawkar, Dinesh; Palle, Venkata Poornapragnacharyulu, PCT Int. Appl., 2011, WO 2011055391 A1 20110512

“Synthesis and antimicrobial studies of some new 3-isoxazoline substituted phthalazine methylsulfonyl oxadiazoles”, Sridhara, A. M.; Venugopala Reddy, K. R.; Keshavayya, J.; Ambika, D. S.; Goud, Sanathkumar; Peethambar, S. K., E-Journal of Chemistry, 2011, 8, 3, 1022-1029, DOI:10.1155/2011/356437

“Synthesis of a novel tetracyclic azaindolo[2,1-c][1,4]benzoxazine ring system”, Kurhade, Santosh; Kaduskar, Rahul D.; Dave, Bhavesh; Ramaiah, Parimi Atchuta; Palle, Venkata P.; Bhuniya, Debnath, Tetrahedron Letters, 2011, 52, 16, 1874-1877, DOI:10.1016/j.tetlet.2011.02.020

“Synthesis of Molluscicidal Agent Cyanolide A Macrolactone from D-(-)-Pantolactone”, Hajare, Atul K.; Ravikumar, Velayutham; Khaleel, Shaik; Bhuniya, Debnath; Reddy, D. Srinivasa, Journal of Organic Chemistry, 2011, 76, 3, 963-966, DOI:10.1021/jo101782q

“Synthesis of novel dihydrooxazine and oxazoline based sugar hybrids from sugar azides”, Kurhade, Suresh E.; Ravula, Sudhir; Siddaiah, V.; Bhuniya, Debnath; Reddy, D. Srinivasa, Tetrahedron Letters, 2011, 52, 33, 4313-4315, DOI:10.1016/j.tetlet.2011.06.035

“Synthesis of novel sugar-lactam conjugates using the Aube reaction”, Kurhade, Suresh E.; Mengawade, Tanaji; Bhuniya, Debnath; Palle, Venkata P.; Reddy, D. Srinivasa, Organic & Biomolecular Chemistry, 2011, 9, 3, 744-747, DOI:10.1039/C0OB00719F

“Synthesis, antimicrobial and cytotoxicity studies of some novel modified strobilurin derivatives”, Sridhara, Ajjanna M.; Reddy, Kallam R. Venugopala; Keshavayya, Jathi; Ambika, Dasannana Malige S.; Gopinath, Vadiraj S.; Bose, Prosenjit; Goud, Sanath Kumar; Peethambar, Sanenahalli K., Journal of the Brazilian Chemical Society, 2011, 22, 5, 849-856, DOI:10.1590/S0103-50532011000500006

“Synthesis, antimicrobial and cytotoxicity studies of some novel phthalazine-methoxyacrylate derivatives”, Sridhara, Ajjanna M.; Reddy, Kallam R. Venugopala; Keshavayya, Jathi; Vadiraj, Suphala G.; Bose, Prosenjit; Ambika, D. S.; Raju, Ch. Krishnam; Shashidhara, S.; Raju, N. Hanumantha, Journal of Pharmacy Research, 2011, 4, 2, 496-500

“Total Synthesis of Isofregenedadiol”, Kurhade, Suresh E.; Sanchawala, Abbas I.; Ravikumar, Velayutham; Bhuniya, Debnath; Reddy, D. Srinivasa, Organic Letters, 2011, 13, 14, 3690-3693, DOI:10.1021/ol201336x

“Degradation studies of pentoxifylline: Isolation and characterization of a novel gem-dihydroperoxide derivative as major oxidative degradation product”, Mone, Mahesh Kumar; Chandrasekhar, K. B., Journal of Pharmaceutical and Biomedical Analysis, 2010, 53, 3, 335-342, DOI:10.1016/j.jpba.2010.04.006

“Direct nuclear halogenation of deactivated aryl and N-heteroaryl amines”, Waghmare, Anirudha A.; Bose, Prosenjit; Pati, Hari N., Pharma Chemica, 2010, 2, 5, 212-241

“Enantiospecific synthesis of sex pheromone of the obscure mealybug from pantolactone via tandem conjugate addition/cyclization”, Hajare, Atul K.; Datrange, Laxmikant S.; Vyas, Samir; Bhuniya, Debnath; Reddy, D. Srinivasa, Tetrahedron Letters, 2010, 51, 40, 5291-5293, DOI:10.1016/j.tetlet.2010.07.166

“Magtrieve (CrO2) and MnO2 mediated oxidation of aldoximes: studying the reaction course”, Bhosale, Sandeep; Kurhade, Santosh; Vyas, Samir; Palle, Venkata P.; Bhuniya, Debnath, Tetrahedron, 2010, 66, 50, 9582-9588, DOI:10.1016/j.tet.2010.10.029

“Preparation of acetamide derivatives as glucokinase activators”, Bhuniya, Debanath; Bhosale, Sandeep Bhausaheb; Kapkoti, Gobind Sing; Palle, Venkata Poornapragnacharyulu; De, Siddhartha; Mookhtiar, Kasim A.; Dave, Bhavesh; Deshpande, Anil; Kurhade, Santosh; Kobal, Balasaheb; et al, U.S. Pat. Appl. Publ. (2010), US 20100310493 A1 20101209

“Protein binding in drug discovery and development”,  Ramanathan, Vikram; Vachharajani, Nimish Edited By:Han, Chao; Davis, Charles B.; Wang, Binghe, Evaluation of Drug Candidates for Preclinical Development, 2010, 135-167, DOI:10.1002/9780470574898.ch6

“Substituted fused pyrimidine compounds”, Palle, Venkata; Ramdas, Vidya; Barawkar, Dinesh; Basu, Sujay; Koul, Summon; Waman, Yogesh; Patel, Meena; Panmand, Anil, PCT Int. Appl., 2010, WO 2010103547 A2 20100916

“Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)]phthalazin-1(2H)-one derivatives”, Sridhara, Ajjanna M.; Venugopala Reddy, Kallam R.; Keshavayya, Jathi; Kumar Goud, Palusa Sanath; Somashekar, Bankavadi C.; Bose, Prosenjit; Peethambar, Sanenahalli K.; Gaddam, Satish Kumar, European Journal of Medicinal Chemistry,  2010, 45, 11, 4983-4989, DOI:10.1016/j.ejmech.2010.08.005

“Synthesis and antimicrobial activity of phthalazine substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 7H-[1,2,4]triazolo[3,4-b]thiadiazines”, Sridhara, A. M.; Reddy, K. R. Venugopala; Keshavayya, J.; Chidananda, B.; Prasad, Yaragola; Kumar, G. Satish; Vadiraj, S. G.; Bose, Prosenjit; Goud, Sanath Kumar; Peethambar, S. K., Pharma Chemica, 2010, 2, 5, 201-211

“Acute toxic effects of Endosulfan 35 EC (Endocel) upon oral gavage and dietary admixture in Japanese quails”, Prakash, P. J.; Rajashekhar, G.; Krishnappa, H.; Sulaiman, S. M.; Rao, K. Venugopala, Research Journal of Environmental Toxicology, 2009, 3, 3, 124-131, DOI:10.3923/rjet.2009.124.131

“Effect of Endosulfan 35% EC on the egg laying and egg shell thickness in Japanese quails”, Prakash, P. J.; Rajashekhar, Geetha; Krishnappa, H.; Sulaiman, S. M.; Venugopala Rao, K., Research Journal of Environmental Toxicology, 2009, 3, 3, 140-146, DOI:10.3923/rjet.2009.140.146

“Efficient synthesis of isoxazoles and isoxazolines from aldoximes using Magtrieve (CrO2)”, Bhosale, Sandeep; Kurhade, Santosh; Prasad, Uppuleti Viplava; Palle, Venkata P.; Bhuniya, Debnath, Tetrahedron Letters, 2009, 50, 27, 3948-3951, DOI:10.1016/j.tetlet.2009.04.073

“Preparation of acetamide derivatives as glucokinase activators”, Bhuniya, Debanath; Bhosale, Sandeep Bhausaheb; Kapkoti, Gobind Sing; Palle, Venkata Poornapragnacharyulu; De, Siddhartha; Mookhtiar, Kasim A., PCT Int. Appl., 2009, WO 2009047798 A2 20090416

“Preparation of pyrimidine compounds as therapeutic adenosine receptor antagonist”, Palle, Venkata; Basu, Sujay; Waman, Yogesh; Ramdas, Vidya; Barawkar, Dinesh, PCT Int. Appl., 2009, WO 2009118759 A2 20091001

“A convenient and practical synthesis of Olmesartan medoxomil methyl ether”, Pati, Hari Narayan; Lahiri, Saswata; Sabbam, Ramesh Kumar; Vangala, Vijaya Bhaskar; Ramalingam, Boobalan; Hiriyanna, Salmara Ganeshbhat; Bose, Prosenjit,  Journal of Heterocyclic Chemistry, 2008, 45, 3, 917-920, DOI:10.1002/jhet.5570450342

“Acridones circumvent P-glycoprotein-associated multidrug resistance (MDR) in cancer cells”, Gopinath, Vadiraj S.; Thimmaiah, Padma; Thimmaiah, Kuntebommanahalli N., Bioorganic & Medicinal Chemistry, 2008, 16, 1, 474-487, DOI:10.1016/j.bmc.2007.09.020

“Preparation of phenoxythiazolylalkylacetamide derivatives and analogs as glucokinase activators”, Mookhtiar, Kasim A.; Bhuniya, Debnath; Dave, Bhavesh; Kapkoti, Gobind S.; Basu, Sujay; Chugh, Anita; De, Siddartha; Palle, Venkata P., PCT Int. Appl., 2008, WO 2008104994 A2 20080904

“Preparation of pyrrole-2-carboxamide derivatives as glucokinase activators and their pharmaceutical application”, Bhuniya, Debnath; Kapkoti, S. Gobind; Warrier, S. Jayakumar; Kukrejka, Gagan; Mavinahalli, N. Jagadeesh; Palle, P. Venkata; Mookhtiar, A. Kasim, PCT Int. Appl., 2008, WO 2008149382 A1

“Simultaneous determination of several angiotensin-II receptor antagonists by liquid chromatography”, Hiriyanna, S. G.; Basavaiah, K.; Dhayanithi, V.; Bindu, A.; Pujari, Sudhaker; Pati, Hari N., Analytical Chemistry: An Indian Journal, 2008, 7, 8, 568-572

“Unusual detritylation of tritylated tetrazole in sartan molecules”, Srimurugan, Sankareswaran; Suresh, Paulsamy; Babu, Balaji; Hiriyanna, Salmara Ganeshbhat; Pati, Hari Narayan, Chemical & Pharmaceutical Bulletin, 2008, 56, 3, 383-384, DOI:10.1248/cpb.56.383

“A facile synthesis of new chiral [1+1] macrocyclic schiff bases”, Suresh, Paulsamy; Srimurugan, Sankareswaran; Pati, Hari N., Chemistry Letters,  2007, 36, 11, 1332-1333, DOI:10.1246/cl.2007.1332

“Isolation by preparative HPLC and characterization of process-related impurities in tebuconazole”, Hiriyanna, S. G.; Sreedhar, K.; Dhayanithi, V.; Reddy, K. V. S. R. Krishna; Vaidyanathan, Gopal; Basavaiah, K., Analytical Chemistry: An Indian Journal, 2007, 5, 1-6, 51-56

“Microwave-assisted synthesis of 72-membered chiral hexanuclear [6 + 6] macrocyclic Schiff base”, Srimurugan, Sankareswaran; Suresh, Paulsamy; Pati, Hari N., Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2007, 59, 3-4, 383-388, DOI:10.1007/s10847-007-9341-0

“Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects”, Mandlekar Sandhya; Hong Jin-Liern; Kong Ah-Ng Tony, Current drug metabolism, 2006, 7, 6, 661-75

Posters/Presentations

“In vitro Metabolism and Disposition of DNDI-VL-2098, a Potential Treatment for Visceral Leishmaniasis”, Rao, MVS; Pinjari, Jakir; Pothuri, Lavanya; Mondal, Subodh; Gopu, C.L.; Prabhakar, K.R.; Launay, Delphine; Martin, Denis; Vachharajani, Nimish; Ramanathan, Vikram., 2011, AAPS, Poster No: R6388

“Preclinical Pharmacokinetics and Prediction of Human PK of DNDI-VL-2098, a Potential Oral Treatment for Visceral Leishmaniasis”, Harisudhan, T.; Pinjari, Jakir; Gadekar, Ajit; Verma, Manas; Patel, Bhavesh; Patel, Jignesh; Moinuddin, F.; Shankar, S.; Rao, MVS; Launay, Delphine; Martin, Denis; Vachharajani, Nimish; Ramanathan, Vikram., 2011, AAPS, Poster No: R6389

“Buparvaquone Pharmacokinetics and its Solubility-Limited Oral Absorption”, Pinjari, Jakir; Badrinath, R; Jayasagar, G; Kanchi, R; Nageswararao, K; Pasha, Mazhar; Rohith, N; Vinay, H Vachharajani, Nimish; Ramanathan, Vikram.,AAPS, 2008, Poster No: M1305

“Hydroxychloroquine Pharmacokinetics and Tissue Distribution in the C57 black mouse”, Raff, Howard; Jayasagar, G; Bhatt, Deepak; Nigade, Prashant; Pinjari, Jakir; Rao, Mukkavilli; Shankar, S; Sivaprasad, Putlur; Vachharajani, Nimish; Ramanathan, Vikram., 2008, AAPS, Poster No: M1315