From Concept to Proof of Concept   

Advinus offers extensive process development, process optimization, cost optimization services to support development of agrochemical molecules. Our state-of-the-art facility at Bangalore is specially designed to undertake synthesis from milligram to multi-kilogram scale. Advinus’ agrochemical chemistry services are provided from a dedicated facility which is separate from its pharmaceutical chemistry facility. Our agrochemical chemistry centre is equipped with sophisticated instruments, a kilo-lab, and pilot-plant for process development and scale-up of agrochemical molecules.

  • Design and demonstration of novel, sustainable synthetic routes for agrochemical active ingredients (AIs) with an emphasis on IP generation, cost optimization, quality, safety, atom efficiency, and green chemistry.
  • Design and development of scalable, robust, safe, and cost-effective synthetic processes using systematic methodologies such as Design of Experiments (DoE), Quality by Design (QbD), etc.
  • Process validation studies to assure products meet specified quality parameters consistently and reliably
  • Process Hazard Analysis (Process Safety Assessment) to identify potential hazards such as uncontrollable exothermic reactions, run-away reactions, unexpected release of toxic or flammable gases etc to eliminate unsafe operations
  • Evaluation of process safety using Reaction Calorimetry (RC) and Differential Scanning Calorimeter (DSC)
  • Modern equipment, utilities, and state-of-the-art scale-up capabilities to synthesize agrochemical active ingredients (AIs)
  • Seamless technology transfer from lab to pilot-plant and to commercial plant for large-scale manufacturing
  • Exclusive services in screening, identification, and evaluation of the best possible morph of agrochemical active ingredient (AI) and developing processes to obtain desired morph of the agrochemical active ingredient (AI) on large-scale.
  • Identification and synthesis of impurities in agrochemical active ingredients
  • Development of analytical methods to isolate impurities in agrochemical active ingredients using various techniques such as flash chromatography, liquid-liquid extractions, and preparatory HPLC.
  • Elucidation of structure of the isolated impurities using MS/LC-MS, and NMR spectroscopy.
  • Preparation of formal report/document for submission to appropriate regulatory agency