From Concept to Proof of Concept info@advinus.com   

Overview

REACH (Registration, Evaluation and Authorization of Chemicals) is the EC1907/2006 Regulation, which entered into force on June 1st 2007 and replaces all previous legislation on authorization of chemicals in the European Union (EU). In fact, it creates a single system for both “existing” and “new” chemicals manufactured in or imported into the EU in quantities greater than 1 ton/year. Although REACH is a European program, it impacts manufacturers worldwide.

According to REACH requirements, industry has the responsibility to ensure that the chemicals it manufactures, imports and puts on the market in the EU do not adversely affect human health or the environment. It requires manufacturers and importers of chemicals into the European Union (EU) to submit hazard, use, and risk data for all substances.

  • REACH ready testing laboratory
  • Capabilities in:
    • Physical and chemical properties testing
    • Mammalian toxicology
    • Aquatic toxicology
    • Avian toxicology
    • Environmental testing
    • Risk assessment
  • Experience of having completed over 10,000 GLP studies till date
  • Our scientists will assist in creating a tailor made testing program and will defend your work with regulators
  • Personalized consulting services
  • Customized testing schemes for each compound
  • Literature services for REACH compounds
  • Advinus’ historical control data from over 24 years of GLP studies
  • Quality at cost effective prices
  • Dedicated project manager for each client
  • Rapid turnaround of data
  • State of the art facility
  • Highly motivated scientific talent

Services for REACH

We are prepared to meet all the physicochemical, toxicity and environmental fate testing needs in cost-effective manner. Below are the details of our offering.

  • Physical state at 20°C and 101.3 kPa
  • Melting/freezing point
  • Boiling point
  • Relative density
  • Vapor pressure
  • Surface tension
  • Water solubility
  • Partition coefficient n-octanol/water (log value)
  • Flash point
  • Flammability
  • Stability in organic solvents and identity of relevant degradation products
  • Dissociation constant
  • Viscosity
  • Sensitization (LLNA)
  • Acute toxicity
  • Genetic toxicology (Ames test, in vitro gene mutation in  mammalian cells, in vitro cytogenicity in mammalian cells )
  • In vivo skin irritation
  • In vivo eye irritation
  • Inhalation toxicity
  • Repeated dose toxicity (28 days)
  • Repeated dose toxicity (90 days)
  • Long term (12 months) repeated dose toxicity
  • Carcinogenicity study
  • Toxicokinetics assessment
  • Developmental toxicity screening tests (OECD 421 or 422)
  • Two generation reproductive toxicity
  • Teratogenicity
  • Immunotoxicity/ Neurotoxicity
  • Bird testing
  • EpiSkin® in vitro Skin Irritation Test (OECD 439)
  • EpiSkin® in vitro Skin Corrosion Test (OECD 431)
  • Acute toxicity with daphnia
  • Growth inhibition on Algae
  • Biodegradation
  • Aquatic toxicity with fish
  • Acute toxicity to honeybee (oral and contact)
  • Abiotic hydrolysis pH
  • Adsorption/ Desorption screening
  • Acute toxicity on earthworms
  • Simulation testing – soil, water, sediment
  • Identification of degradation product
  • Acute Toxicity in birds
  • Avian Dietary Toxicity in birds
  • Avian Reproduction Test